Liposomal vitamin C by Livon Labs - Doug Cook RD

Liposomal Vitamin C vs Regular Vitamin C

Vitamin C Carton 2017 10 - Liposomal Vitamin C vs Regular Vitamin C

Vitamin C is probably one of the best-known vitamins around.


Growing up, we always had a bottle on the kitchen table, conveniently found on the ‘lazy Susan’. W


e typically had chewable, orange-flavored tablets in either 250 mg or 500 mg dosages.


Taking one with breakfast, along with a multivitamin with minerals was just part of my family’s morning routine at breakfast.


My mother instilled the importance of good nutrition at an early age, whether she was aware of it or not, and the foundation for the proper use of a dietary supplement was also laid.


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What is vitamin C?

Vitamin C, or ascorbic acid, is one of the 50 essential nutrients you need every day for optimal health.


Vitamin C is water soluble meaning it’s found in bodily compartments that are water-based such as the blood, in the spaces in between cells and within cells themselves. Because vitamin C isn’t fat soluble, it doesn’t make its way into fatty tissue such as your fat cells or within the fatty part of the membrane that makes up the cells of your body.


Human beings have lost the ability to make their own vitamin C, unlike most other animals. Therefore, we must get it from our diet (or supplements).


Vitamin C is an essential cofactor in various biochemical reactions such as collagen and carnitine synthesis, regulation of gene expression, immune support, neuropeptide production and more.


Vitamin C - Liposomal Vitamin C vs Regular Vitamin C

What does vitamin C do?

Besides being a cofactor in various biochemical reactions, vitamin C is a powerful antioxidant.


What is oxidation? Think of it this way. Oxidation is what happens to an apple core when it’s exposed to the air, it browns or when an iron nail is exposed to water and oxygen; it rusts.


Oxidation of bodily structures like protein, fats, carbohydrates, and even the DNA, found in all tissues and organs, increases inflammation and the risk for chronic degenerative diseases. In the case of DNA, oxidation can lead to mutations increasing the risk of cancer.


Vitamin C helps to prevent this from happening. It protects you from dangerous compounds generated during normal metabolism. Vitamin C also protects you from free radicals from exposure to toxins and pollutants.


These toxins include first or second-hand smoke, exposure to, and the metabolism/breakdown of recreational and prescription drugs.


Other toxins include alcohol, air pollution, inflammation from trans fats and diets high in sugar and refined carbohydrates. You’re exposed to toxins produced by viruses, bacteria and other pathogens that your immune is faced with every day.

 What are the benefits of taking vitamin C?

There are many benefits from getting more vitamin C in your diet and by including vitamin C supplements. Vitamin C is a versatile nutrient that supports your health in many ways including*:

  • Helps the body to metabolize fats and proteins.
  • A factor in energy production
  • Aids in the development and maintenance of bones, cartilage, teeth, and gums.
  • It helps in connective tissue formation.
  • It helps with wound healing.
  • An antioxidant for the maintenance of good health.
  • Protects against free radicals and the damage & oxidative effects of free radicals
  • Helps to prevent vitamin C deficiency
  • Supports a healthy immune system & reduces the risk of chronic diseases
  • Supports collagen production for healthier skin, muscles, ligaments, cartilage and joints
  • Improves the appearance of skin; more supple, improved clarity [see details about skin study below]
  • A dietary antioxidant that significantly decreases the adverse effects of free radicals on normal physiological function & lipid oxidation in body tissues
  • Supports optimal overall health

* Health Canada approved health & function claims


However, vitamin C is only as good as its ability to be where it needs to be and in amounts known to confer the greatest benefit. This why lypospheric technology is arguably superior for delivery of nutrients. If these formulations are absorbed and distributed throughout the body better, what are some liposomal vitamin C benefits?

What are liposomes?

A liposome is a very tiny sphere comprised of an outer wall of fat (membrane) and an inner payload of any number of water-soluble substances. Of particular interest is that the liposome’s membrane is made of the same fat found in the cell membranes throughout your body: phospholipids.


Because of this, liposomes have actually been studied as artificial models of cells. However, liposomes are vastly smaller than any of the cells in your body, allowing them to pass into cells without difficulty.


What really makes the liposome so special is that can deliver its contents (nutrients) directly into the cells of your body without the consumption of energy. An added bonus, liposomes protect its contents from digestion or oxidation before the final delivery into your cells.


When a nutrient can be delivered into the cells of your body, not be degraded before delivery, and not consume energy in the process, the benefits of that nutrient can be optimized in a way that even intravenous delivery often does not match. Liposomal vitamin C is great for that reason.

What Are The Benefits Of Lypo Spheric Vitamin C?

Lypo Spheric vitamin C is no ordinary supplement. It delivers more vitamin C to where it’s needed most because of its unique structure. Lypo-spheric technology is arguably superior for the delivery of nutrients. Why is liposomal vitamin C better? Check out the reasons below.

Better absorption

Regular vitamin C does have a disadvantage making vitamin C supplementation different from other nutrients.


Much of the vitamin C you take orally, either from food or supplements, isn’t absorbed by the gut. Smaller amounts are absorbed better, e.g. if you took 100 mg, you’d absorb about 98 mg. There’s a larger “fractional absorption” amount with smaller doses.


The fractional absorption amount decreases though with larger doses. Only about 1000-1250 mg of vitamin C would be absorbed with a single 2000 mg dose. True, more total vitamin C is absorbed but it’s less efficient. To put this in perspective, a single 12,000 mg dose would only result in about 16%, or 1920 mg, of it being absorbed.


Pharmacokenetics of vitamin C.


Vitamin C must be transported through the gut wall using transporters. There are only so many transporters available and this action requires energy. Also, there only so much time before vitamin C moves along on its merry way down your digestive tract. Once vitamin C has moved on, it’s lost its chance to be absorbed. As you can see, there are limitations to the absorption of traditional vitamin C.


Also, regular vitamin C is quickly absorbed, distributed throughout the circulation and then eventually filtered, and excreted by the kidneys.


Once taken, blood levels peak about 2 to 4 hours afterward and then drift back down to pre-supplementation (baseline) levels about 6-8 hours after that. If you want more from your regular vitamin C, several doses need to be taken throughout the day.


Needless to say, this can make oral dosing of vitamin C somewhat burdensome.


Once in your bloodstream, a portion of the vitamin C will diffuse or be actively transported from the blood into the various cells of your body such as your muscles, heart, kidneys, liver, digestive tract, your brain, eyes, etc.


Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia–Reperfusion Injury


It does offer antioxidant protection but the amount of vitamin C that gets into your cells is much less than the amount that’s in the bloodstream (outside your cells). Much of the vitamin C that doesn’t get absorbed by your cells will be excreted in your urine. This is why liposomes are better and lypospheric vitamin C offers greater benefits.


Being wrapped in essential phospholipids, vitamin C is absorbed like dietary fats. It is taken up by the lymphatic system with an estimated 98% efficiency. Once there, it moves from the lymphatic system into your bloodstream. Liposomes deliver more vitamin C into the circulation compared to traditional vitamin C supplements.


The circulating vitamin C-rich liposomes deliver more vitamin C to your tissues and organs. The liposomes bind to the cell membranes where they release vitamin C into your cells, effectively raising INTRA-cellular levels.


A recent clinical trial by world-renowned vitamin C expert and pharmacologist, Steve Hickey, Ph.D., showed that liposomal vitamin C was able to produce serum levels of vitamin C nearly double those thought theoretically possible with any oral form of the vitamin.


This astounding level of bioavailability not only dramatically increases the amount of vitamin C in the blood, but recent thermographic microscopy provides visible evidence that it also aids its entry into individual cells.


Even IV vitamin C has its limits in terms of raising intracellular levels of vitamin C because most of the vitamin C is still in the blood. Some of it will find its way into the cells, but not much. Studies estimate that only about 20% of the vitamin C from IV delivery gets in despite very high concentrations in the serum. Liposomal C is different.


Anecdotally, vitamin C researcher Thomas Levy has found through years of clinical experience that a much smaller oral dose of lypo spheric vitamin C (5 to 10 grams) often results in a similar clinical response as a much larger dose of vitamin C given intravenously (25 to 100 grams).

Source of essential phospholipids

It’s not just about the vitamin C. When you take liposomal products, you’re getting all the nutritional benefits of the material that the liposomes are made from. Liposomes are made of phospholipids with a high concentration of phosphatidyl-choline, which is a building block of all of your cellular structures including cell membranes.


It’s the unique phospholipid-based structure of liposomes that allows them to ‘slip’ through the cell membrane (without needing energy to do so), into your cells, where vitamin C is needed most.


Phosphatidyl-choline is a specific type of essential fats (phospholipids) that your body can’t produce on its own so you need to get it from food. As a structural feature of your cell membrane, phospholipids are needed for ongoing repair and maintenance.


Liposomes are a supplemental source of phosphatidyl-choline which, in turn, provides your body with much-needed choline. Most people don’t get enough choline and its importance in human health has been largely forgotten. To learn more, read my post Choline. Always A Bridesmaid, Never A Bride.


Each sachet of a LivOn Lab lypo spheric product has 75 mg of choline.

What is liposomal vitamin C used for? 

Better bioavailability

Liposome encapsulation overcomes all the bioavailability and cellular uptake restrictions. Liposomes do not rely on a specialized carrier transport system. Instead, due to their size and composition, they are able to be passively absorbed through the intestinal wall and through cellular membranes.


As a result, liposome encapsulated nutrients (like lypo spheric vitamin C and liposomal glutathione, lypo spheric carnitine, and lypo spheric alpha lipoic acid) provide a greatly enhanced bioavailability (delivery into the bloodstream) and greatly improved delivery into individual cells.


This better absorption has the advantage of the vitamin C entering the lymphatic system first, giving up a lot of its vitamin C to your white blood cells of the immune system (such as the macrophages and phagocytes that love to concentrate vitamin C within their structures to fight infections and cancer).


The vitamin C filled liposomes then enter the bloodstream but unlike regular ascorbic acid that is filtered by the kidneys, when liposomal vitamin C is cleared from the blood it is taken up by various cells, tissues, and organs throughout the body. It makes its way into your cells and is not lost in your urine.


PRO TIP: One form of vitamin C doesn’t, nor shouldn’t, replace the other. Regular vitamin C increases blood levels nicely while lypospheric is better at increasing the vitamin C within your cells. It’s best to have both forms to ensure maximum benefits!


Reproduces our hypothesized lost ability to synthesize our own vitamin C

Now, here’s where it gets interesting. This concept will be new to most people.


Along with primates and guinea pigs, humans are the only other mammal on Earth incapable of making our own vitamin C. It’s true.


The Genetics of Vitamin C Loss in Vertebrates


Goats, dogs, cats, elephants, pigs, horses, and other mammals make their own vitamin C [in their livers and/or kidneys] and they make it in HUGE amounts. Much more on a per kg of body weight basis than what’s recommended for human health. Much, much more than the 90 mg or so per day recommended for adult humans.


But researchers say it wasn’t always like that. Our earlier ancestors used to make their own vitamin C.


Ridiculous Dietary Allowance – A Challenge to the RDA for Vitamin C


We’re missing the enzyme L-gulonolactone oxidase (GLO) needed to do this for ourselves.


You and I have the gene in our DNA that’s responsible to make the GLO enzyme [and by extension vitamin C], but it’s mutated. Because of this, our liver cells can’t ‘read’ the gene and are unable to finish the final step of making vitamin C from glucose. Not only do we have all the other genes to make vitamin C, all of those genes are active in us except for the last one.


Vitamin C biosynthesis - Liposomal Vitamin C vs Regular Vitamin C


Note. In the diagram above, you and I (mammals) can do everything needed, up to the last step:  L-GulL to L-ascorbate a.k.a. “vitamin C”


What is vitamin C? How does it function biochemically? Why can’t humans synthesize it?


It’s for this reason that some researchers think vitamin C [and the inability to make it] should be reclassified. That vitamin C production defects should be seen as an “inborn error of carbohydrate metabolism”.


Researchers theorize that once, long ago, we produced large amounts of vitamin C just like those animals that can make it themselves do. For example, a 150 or 72 kg goat can produce up to 13,000 mg of vitamin C per day. More when it’s under stress.


Homo sapiens ascorbicus, a biochemically corrected robust human mutant.


Animals that produce their own vitamin C do so all day long, 24/7. As a result, they have both higher levels of vitamin C in their blood and within their cells. A liposomal vitamin C benefit is one where it raises your INTRA-cellular (within the cell) levels of vitamin C like it would if you made your own vitamin C all day long. Like a goat.


Liposomal vitamin C benefits you by mimicking the hypothesized, long lost ability to maintain higher levels of vitamin C in both your bloodstream and within your cells like they would have been when our long ago ancestors made their own.

Better delivery of vitamin C to maturing white blood cells

As mentioned, your immune system LOVES vitamin C.


Your adrenal glands do too. Like white blood cells, your adrenals selectively take up vitamin C from your bloodstream and concentrate in their respective cells but I digress [hint, vitamin C helps with stress tolerance].


Vitamin C bolsters your immune response. It is the premier antioxidant circulating throughout your body but vitamin C does more. Studies have clearly established vitamin C’s ability to directly promote and stimulate a number of very important functions of your immune system.


These functions include the following:

  • Enhanced antibody production (B-lymphocytes, humoral immunity)
  • Increased interferon production
  • Enhanced phagocytic (scavenger cell) function
  • Improved T-lymphocyte function (cell-mediated immunity)
  • Enhanced B-lymphocyte and T-lymphocyte proliferation. Enhanced natural killer cell activity (very important anti-cancer function)
  • Improved prostaglandin formation
  • Increased nitric oxide production by phagocytes


Can vitamin C reduce cold duration?


Phagocytic white blood cells (granulocytes) have 25X more vitamin C than what’s in the blood. Vitamin C is ‘used up’ when these cells digest pathogens and cellular “debris”. Phagocytic cells are like PACMANs, moving about the body, gobbling up the bad guys.


The biggest consumer of vitamin C in the immune system though, are the monocytes. These are also known as macrophages; another cell with phagocytic functions. They are vitamin C hogs. Monocytes have more than an 80X increased concentration of vitamin C inside it relative to the blood.


Ascorbate – The Science of Vitamin C


Lypo spheric vitamin C benefits the immune system because of the structure of the liposome. Because it’s absorbed as fat, liposomal vitamin C enters the lymphatic system where it is transported to the lymph nodes throughout the body.


Once there, the liposomes release the vitamin C into the maturing blood cells so that when released into the bloodstream, they are ‘supercharged’, ready to fight the good fight and keeping your healthy.

Study: Liposomal vitamin C improves skin quality

Sun damage is considered one of the main causes of skin aging mostly because UV radiation breaks down the skin’s supportive and structural proteins, collagen and elastin. Because vitamin C is needed for optimal collagen production, researchers wanted to know if liposome encapsulated vitamins might play a role in antiaging nutrition.


In a December 2014 study by Princeton Consumer Research Ltd., researchers conducted a double-blind placebo-controlled study to assess the impact of liposomal vitamin C on skin firmness and wrinkling.


Compared to placebo, those who took 1000 mg of lypospheric vitamin C per day saw a 35% increase in skin firmness and an 8% reduction in fine lines and wrinkles whereas those who took 3000 mg per day saw a 61% increase in skin firmness and a 14% reduction in fine lines and wrinkles.


The results are believed to be due to the fact that vitamin C is needed for the production of collagen and elastin, the skin’s supportive structural proteins, and because phospholipids are fats that make up all cell membranes.


Liposomes are the best way to deliver these nutrients into the skin cells. Liposomal vitamin C is the way to go.

Liposomal vitamin C side effects

Lypo spheric vitamin C is very well tolerated. There are no known meaningful liposomal side effects when reasonable doses are taken.


Safety studies have shown that 1 to 5 g per day are well tolerated. In studies where very large doses are taken, 20 – 30 g, some subjects experience some gastrointestinal upset.


This is thought to be due to the phospholipid content. Large intakes of fat can cause some gas, bloating and flatulence. Smaller doses spread out over the day is a good dosing pattern.


To learn more watch this video What is Lypospheric (Liposomal) Technology?

Bottom line

Vitamin C is one of the best-known vitamins around. This is largely due to the work done in the 1970s by Linus Pauling, an American biochemist and engineer.


His books How to Live Longer and Feel Better and Vitamin C and the Common Cold were two seminal works that lead the way to the two fantastic documents listed in this post Ridiculous Dietary Allowance – A Challenge to the RDA for Vitamin C and Ascorbate – The Science of Vitamin C


At the time, Pauling and others didn’t have the understanding that we do today regarding how vitamin C is absorbed, distributed and ultimately excreted by the body. We know better today and to cite limitations from the 70s and 80s is a common response to anti-supplement crowd.


Vitamin C serum levels are influence by both the amount of vitamin C taken and how often. Small amounts, taken frequently are better absorbed when it comes to regular vitamin C such as ascorbic acid or sodium ascorbate.


Fast forward to today, and liposome encapsulated vitamin C overcomes the historical limits of regular vitamin C supplementation.


Lypospheric vitamin C is a superior formulation that increases the amount of vitamin C that gets into cells and tissues.


Because it’s transported and metabolized differently (in phospholipid spheres), lypospheric vitamin C isn’t as effective at increasing serum, and interstitial concentrations like regular vitamin C does which is why it’s best to take both formulations if you decide to supplement with vitamin C.


One form of vitamin C doesn’t, nor shouldn’t, replace the other. It’s best to have both forms to ensure maximum benefit!


Vitamin C pour - Liposomal Vitamin C vs Regular Vitamin C


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Doug Cook RDN is a Toronto based integrative and functional nutritionist and dietitian with a focus on digestive, gut, and mental health.  Follow me on FacebookInstagram and Twitter.

Comments 66

  1. Gwyn C Mountfield
    July 18, 2019

    You do not mention what type of Vitamin C you use. Do you use natural Vit C or Ascorbic Acid, which is synthetic Vit C, Chemically similar but nutritionally dissimilar. Would you clarify please.

    1. Doug Cook
      July 18, 2019

      Ascorbic acid is ascorbic acid…the biochemistry is the same. Ascorbic acid is the biochemical term for “vitamin C”. I have loads of papers on the pharmcokentics of ascorbate if you’re interested. Do you have papers to suggest otherwise? I’m always open to learning. Yes, ascorbic acid can be made from the isomerization of glucose but it’s used by the body in the same way…

      1. Old Dog
        August 20, 2019

        chemically its same, but ascorbic acid is produced artificially mainly through microbes and funghi. and 99% of all synthetic vitamin c comes from china.

        its chemically same but not pure. there are always little things from production which shouldnt be there like fungal spores or toxins.
        those certificates for purity only test a few things. they find only what they are searching for. its financially impossible to search for everything so you can consider those certs a scam.

        wanna see what happens when toxins come through even with clean vertificate? checkout the tryptophan scandal which killed thousands of people.

        1. Doug Cook
          August 20, 2019

          Thanks for your comments…I’m old enough to remember the isolated tryptophan issue…given the volume of supplements on the world stage, can you point me to the verified studies, reports and other to confirm what you’re saying? I’ve got a huge appetite for learning…awaiting the data…regards

          1. Dr. Brian Schroeder D.C.
            April 9, 2020

            Doc Schroeder
            What about the fact that any lab synthesized Vit C always produces a racemic mixture of 50% L molecules and 50% R molecules, and since nature only produces L Vit C, half of your dose is not recognized by the microbiome mucosal cells and is not transported nor absorbed into the blood at all? I just meant synthetic ascorbic acid in general, not necessarily the sodium ascorbate used in Livon’s liposomal product. Just commenting on effectiveness of natural vs synthetic Vitamins.

          2. Doug Cook RDN MHSc
            April 10, 2020


            Can you prove me with some peer-reviewed, primary research on this? Biochemistry, chemistry, pharmacokinetic studies, etc? Regarding transportation issues, I’d love to see some vitamin C studies using isotopes etc to qunatify this, I’m a voracious reader and am always open to learning more…thanks in advance

  2. Glorya
    July 20, 2019

    nice article! This article can help me understand that vitamin C has many benefits
    Did you know that vitamin C can prevent cardiomyopathy due to Oxidative Stress Exposure? check here: prevent-kardiomiopati-akibat-pajian-stresor-oksidatif/

    thanks for sharing!

    1. Doug Cook
      July 20, 2019

      Not surprised, it’s such a potent, effective and universal antioxidant….!

  3. stan b
    September 26, 2019

    I take 20 ml. a day. How does that break down in dose terms . its in liposomal form. some days I take 2 doses. what is your opion of my regimen.

    1. Doug Cook
      September 26, 2019


      I use Livon Labs brand, so I don’t know about yours. The label should provide that information, re: your dose, it’s different for everyone. Basic maintenance is 1 g of vitamin C per day so whatever that is with your brand, that’s a good starting dose

  4. Robynne
    October 8, 2019

    How much Liv on liposomal Vitamin C can you take each day if you are dealing with Cancer? (2-4 packets a day?
    Are there any concerns regarding how much phosphatidylcholine you consume each day?

    1. Doug Cook
      October 8, 2019


      I can’t answer that actually, in terms of treatment but studies have used 10 g or more per day in general health – as way of general information, people routinely take 2 to 4 packets a day. The liposomes are just the same type of lipid found in human cells and 4 g of vitamin C is

      1. Karen Pavy
        July 16, 2021

        I have mild gastritis and do best with eating foods that have a ph of 4 and greater. Would this form of Vit c be less acidic? Thank you!

        1. Doug Cook RDN MHSc
          July 17, 2021

          mineral ascorbates, e.g. calcium ascorbate etc…

    2. Doug Cook
      October 8, 2019

      Regarding the phospholipids, the amounts are minuscule compared to what you get in food

  5. Harry
    October 25, 2019

    If I take 18-20 gm regular vitamin c .How many gm liposomal vitamin c should i take.

    1. Doug Cook
      October 26, 2019


      they’re not really interchangeable as they’re used differently by the body if that’s what you mean. More regular vitamin C stays in the blood and the water sections between the cells called the interstitial fluid. Lipo C gets into cells better via the liposomes and doesn’t provide the same effects in the blood etc like regular vitamin C…..both work best together….for general health, 1 to 2 Lypospheric Cs are taken in addition to regular vitamin C

  6. Colin
    January 7, 2020

    Is there a comparison between LivOn liposomal vitamin C and Dr Mercola product.
    I ask because I read a review by LivOn which rubbished Dr Mercola liposomal vitC.
    Could this be sour grapes?
    Maybe you could do a review of both for us because Dr Mercola has very good reputation and doesn’t usually sell rubbish.

    1. Doug Cook RDN MHSc
      January 7, 2020

      I’m not aware of any formal head-to-head comparison. Livon Labs might have some insight if you want to contact them. I suspect there’s a difference in product standards as there is with all products on the market, whether or not those differences ultimately make a difference is unknown until a study specifically comparing them is done.

      I don’t have a lab to conduct those studies or the expertise as I’m not a researcher, and one couldn’t just take them say something like “I feel just as good or better”…that’s not evidence in the scientific circles….differences have to be measurable, verifiable, reproducible etc, a.k.a. the scientific method

  7. Anita M Whitacre
    January 27, 2020

    Hello, I just discovered this site and am so thankful I did! I have been researching Vit C recently in hopes that adding it in will help with cartilage degeneration. May I please ask you what is the type and amount I should consider adding of “regular” Vit C, in addition to beginning Liposomal C? And how do I figure out how much liposomal to take as well? Thank you so much, Anita

    1. Doug Cook RDN MHSc
      January 27, 2020


      Thank you for the feedback, glad it’s helpful. Regarding doses, I can’t give recommendations as there are no specific guidelines on this (vitamin and cartilage repair) and believe it or not, it’s considered practicing medicine without a license; giving doses for treating a condition. You might find some interesting information at – sorry I couldn’t offer more.

  8. Ken
    February 15, 2020

    Hi Doug, thank you for the article, it was very informative and eye-opening. I am still unclear about one thing, though. You mention that liposomal vitamin C “delivers more vitamin C to where it’s needed most” – if this is the case, why bother taking regular vitamin C if liposomal will deliver vitamin C to the areas that need it the most, in the most effective and efficient manner? What is the benefit of having higher interstitial/serum concentrations of vitamin C as opposed to just having it be delivered directly to the cells? What good is a high vit C concentration in the interstitial fluid/blood if it doesn’t get absorbed by the cells? I see in a response to a comment you mention they are used differently in the body but how so? You are right that it is somewhat burdensome to be drinking sodium ascorbate solution constantly throughout the day and if liposomal is a better delivery of vit C than traditional vit C, I’d prefer to just take liposomal, unless there is an added nutritional benefit to having higher interstitial/serum concentrations. Plus my stomach gets upset if I take too much vit C (which apparently does not take too much vit C for this to happen to me) while I do not get that same side effect with liposomal. Thanks in advance, I am very curious and interested in learning about the previously unknown benefits of vitamin C.

    1. Doug Cook RDN MHSc
      February 16, 2020

      In the post I believe I say both are good as lipo C is encapsulated so the serum and interstitial fluid don’t get the benefits of higher amounts of ascorbic acid in those compartments (antioxidant, antiviral etc) whereas lipo C gets more into cells….if I had to choose one, ut would be lipoic but luckily I don’t have to choose 😃 so I take both 🤓

  9. Lilou
    February 26, 2020

    Hello Doug,
    In this article you explain what is oxidation on the example of an apple.
    As a nutritionist, please tell me is it good to eat oxidized apple? I mean is it good for our health to expose an apple on the air and eat it after it browns?

    1. Doug Cook RDN MHSc
      February 26, 2020

      I wouldn’t worry about it, is this something you like to do?

  10. Lilou
    February 27, 2020

    I have heard that the oxidized fruits are more beneficial for the health, is not it ?
    I am just interested.

    1. Doug Cook RDN MHSc
      February 27, 2020

      No clue…never heard of that suggestion but maybe there’s evidence somewhere!

      1. Lilou
        February 27, 2020

        Ok Doug, thank you very much for your response.

    March 3, 2020

    Good evening.

    I’m Dr LABREZE (MD) fron France.
    I’m taking 10 to 12 grams of C vitamin for 35 years and prescribe large amount for over 30 years as a MD.
    I’m interested in Liposomal C, but I can’t find scientific articles wich really demonstrate the efficiency of C liposomal. Do you know some ?
    Thank you for your help.
    Best regards.

    1. Doug Cook RDN MHSc
      March 3, 2020


      not sure if there are any RCTs etc, you may want to contact LivonLabs headoffice in the US via their website, I think I have a paper on absorption which I’ll send. Regards

  12. Ivan Clark
    March 6, 2020

    Very helpful

  13. Dr. Jimmie McClure, Functional Neurologist
    March 19, 2020

    My thinking in Functional Medicine is: You can either measure and monitor, or you can guess.
    There are Urinalysis Chemstrips that measure Ascorbic Acid levels in 60 seconds from a urine sample, which show gradations of deficiency by color change, by direct measurement. $28.00 on eBay for a canister of 150 test strips. It is amazing how many people are deficient in Ascorbic Acid, and how many have chronic UTI and no symptoms.

  14. Sharon L. Cundiff
    March 30, 2020

    I currently take American Health Ester-C with Citrus Bioflavonoids Veg Tablets – 24-Hour Immune Support, Gentle On Stomach, Non-Acidic Vitamin C – Non-GMO, Gluten-Free, Vegan – 1000 mg, 180 Count, 180 Servings – two capsules a day for 2000 mg. without bowel issues. I enjoyed this article on liposomes as of late I had been hearing about it but hadn’t a clue. Now I do and will add Liposome to my wellness arsenal. The link takes me to your store with only one product available and it is not the Liposome C. Amazon has one item – 12 cartons for $479.00 Liv on Labs is no longer taking orders. Three questions – can you provide another resource for Liv on Lab products? Do you have a runner up recommendation for Liposome C? What dosages of each, my current Ester-C and additional Liposome C do you recommend? Relevant information is that I am a Sjogren’s patient with secondary Lupus and RA and EDS. Currently I take Azathioprine 2 tablets at 50 mg. each.

    1. Doug Cook RDN MHSc
      March 30, 2020


      I don’t make recommendations anymore as I’m not practicing outside of my day job at a hospital and even if I were doing private practice, it’s illegal to give out any kind of advice without being ina formal consultative relationship I’m afraid – sorry!

    2. Doug Cook RDN MHSc
      March 30, 2020

      I’m just a distributor, for more information, contact LivonLabs directly, they’re the best to answer questions and provide resources

  15. Bill
    March 30, 2020

    A Dr. Mercola put on his website liposmal 100 go to 200 a day.

  16. Bill
    March 30, 2020

    That’s 100 to 200 gm

  17. Stuart meigh
    April 17, 2020

    Hi, great article, thanks for writing. 2 questions. I take around 15 grams per day vit C powder and 2 sachets of of liposomal C from livestrong. I also take methotextrate and sulfazalazine and folic acid and Naproxen for Rheumatoid arthritis. I have tried to stop the RA medication and up the vit c, but my body just will not have it. Do you think there could be any contradictions between the vit C and RA meds?

    Also, I really hope I don’t get corona virus!, but if I did, what sort of levels of vit c and liposomals should I be thinking of taking?


    Stuart Meigh

    1. Doug Cook RDN MHSc
      April 17, 2020

      I can’t give any kind of recommendations or advice online, without proper assessments etc, as a regulated health professional, it’s illegal, other ‘health coaches’, ‘nutritionists’, health food store clerks etc can, but as a dietitian I can’t


  18. Hannah
    April 24, 2020

    You can look up many clinical studies on Vit C going back many decades at doctoryourself dot com or orthomolecular dot org. The various doctors / researchers (Drs. Saul, Cathcart, Klenner, etc.) always say take what your body needs in divided doses throughout the day to bowel tolerance, regardless of diagnosis. Your body will tell you when to stop – flatulence being the first sign, then loose stools. I personally take 3 grams of liposomal Vit C and at least 3 grams of regular Vit C in divided doses throughout the day and every day as a maintenance dose. I’ve gone up to more than 20 grams in a 24 hour period when I caught a nasty flu several years ago and never hit bowel tolerance – mostly because my body wanted healing sleep. It’s great stuff!

    1. Doug Cook RDN MHSc
      April 24, 2020

      I’m familiar with those papers and research, I also have 2 great documents in you haven’t read them on vitamin C that I can send and check out

  19. Hannah
    April 24, 2020

    Very cool. Thanks, Doug! Great article and service you provide. Be well.

  20. Sam
    May 1, 2020

    In lipsomal vit C is encapsulate the Vit C with liposomes which is a broadly a formula of ascorbic acid, phospholipids and sodium ascorbate. So why does adding these extra couple of ingredients make it so much more expensive? On the surface, the phospholids appear to be a simple oily lubricant so in theory your intestine thinks differently about the the Vit C i.e. as a type of fat instead of an acid. I’m sure there is a complex science behind this but mixing ascorbic acid with a lubricant seems somewhat simple so maybe I just need to mix sunflower oil with my AA powder to get the same lipsomal result?

    1. Doug Cook RDN MHSc
      May 1, 2020

      Best place to get answers on formulation etc and costs is the manufacturer

      1. Sam
        May 2, 2020

        Thanks Doug, prior to my comment in this thread I already contacted Altrient to provide me with clinical trial reports to evidence their product does indeed increase Vit C levels in the blood plasma (no response as yet)

        As a distributor did they provide you with any research you can share?

        There are a couple of clinical trials on PubMed using lipsomal encapsulated Vit C and these did find higher levels of Vit C using orally ingested lipsomal Vit C.

        I also asked for the rationale behind the sachets being once a day 1000mg dose. Given the clinical evidence the body seems not to be able to absorb this level of Vit C in one hit it seems an inefficient dosage. Again it would be the clinical study data that supports this.

        1. Doug Cook RDN MHSc
          May 2, 2020

          I’ll send some papers I’ve found on the pharmacokenetics to your email on this comment, but feel free to contact them too, there’s no reason not to, they’re open to this

  21. Stephen
    June 29, 2020

    I recently saw a young female Ph.d researcher, I believe on a video on Youtube, claim that you needed to take 5,000mg of liposomal C for it to raise serum levels of C above that achieved by taking ordinary ascorbic acid. Below this level of consumption, liposomal C did no better than ordinary C. Unfortunately, I cannot find this video or any such similar claim about liposomal vs ordinary C anywhere on the Internet. She was certainly pro supplements. Comments please!

    1. Doug Cook RDN MHSc
      June 29, 2020

      Maybe you’re referring to this?

    2. Doug Cook RDN MHSc
      June 29, 2020

      I’ve seen the video, but the question isn’t just about blood levels as is talked about in the blog post, it’s the way it’s absorbed and moved about (pharmacokenetics). Oral and IV vitamin C that makes its way into the bloodstream acts within the watery compartment (The blood and space in between the cells) better than liposomal in the sense that the ascorbic acid is ‘dissolved’ in the blood. The liposomes encapsulate the ascorbic acid and allow vitamin C to transported to cells where it carries more of the vitamin C into cells…only a small amount of regular vitamin C (oral/IV) gets into cells, I’ve read before, about 20%. So oral/IV can raise levels in the blood more with multiple dosing, liposomal will get more delivered into the cells throughout the body – it’s a bit apples and oranges – for health, it’s best to take both forms….I’m interviewing Dr Thomas Levy this Friday on this if you want to check out my podcast in a month or so….

  22. Sue
    June 29, 2020

    does the product contain soy and if so why?

    1. Doug Cook RDN MHSc
      June 29, 2020


      I know nothing about the decisions that went into their formulations, best to contact the company directly

  23. Lydia Yu
    August 21, 2020

    Hi! I just started taking Core Liposomal Vit C 1 gram a day. I was told Liposomal keeps one alert. Does it affect the ears and cause vertigo?

    1. Doug Cook RDN MHSc
      August 21, 2020


      Never heard of that – liposomes are made of phosphatidylcholne, same kind of lipids found in foods like likely not

  24. Sherell Neveu
    October 28, 2020

    I agree with you

  25. Gregory Kleinig
    December 11, 2020

    I have just started taking Lypo-Spheric Vitamin C to help fight Prostate Cancer. I am also taking Mebendazole concurrently, 200mg 3 times per day.
    Currently I am taking the Lypo_spheric VC as a 4g dose first thing in the morning on an empty stomach and 1g later in the day. I weigh 125 kg but am a solid very fit 65 year old. I have stopped eating Carbohydrates and sugars as much as is possible. I make a fresh multi-vegetable and fruit juice combo of which I drink about 1 ltr each day.
    I was due to have my prostate removed in two days time but decided to commit to this program then have another MRI in 6 weeks to see what is happening with the tumour.
    Would I benefit from spreading out the large dose of L-S VitC?
    Should I be taking more given my weight?
    Many thanks for any advice you can give.

    1. Doug Cook RDN MHSc
      December 12, 2020


      I can’t give any health advice over the internet like that, unfortunately. I also don’t have research to indicate what dosing regimen is better for lipo C for any kind of benefit related to cancer….IV vitamin C studies show you need a lot, 25+ g, of IV vitamin C to have anti-cancer effects but how that translates to lipo C is unknown. Regarding prostate cancer, you might want to do some ‘research’ into other nutrients and foods like tomato products/lycopene, omega-3 fats (from fish and seafood), vitamin D3, zinc, selenium, sterols/pumpkin seeds. A good vitamin C resource is,, or


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