Iodine atomic number and iodine mass - by Doug Cook RD

Iodine And Mental Health. What’s the Connection?

Iodine including molecular weight and atomic number

Say iodine and most people think of goiter; the big bulge that people with severe iodine deficiency develop in their necks.


The bulge is nothing more than an enlarged thyroid gland. Normally, as blood flows through the thyroid, it absorbs all the iodine it needs.


But if a diet is chronically low or deficient in iodine, the thyroid grows in size attempting to grab whatever little iodine it can find in the blood stream.


A larger thyroid = more thyroid tissue trying to sponge up more of this precious mineral.


A woman with a large goiter due to iodine deficiency - by Doug Cook RD


What is iodine?

Iodine is a mineral just like iron, magnesium and calcium are. It’s found in some foods but not all. The amount of iodine in fruits, vegetables, grains, nuts and seeds depends on the iodine content of the soil those foods were grown in.


For this reason, the iodine content of similar foods can vary. Other factors that can influence the iodine content include fertilizer use and irrigation (Ref).

How does iodine work?

The body needs iodine to make the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Iodine is an crucial component of these hormones. What do thyroid hormones do? They control your metabolism (helping the body turn food into energy), maintains an ideal body temperature and other important bodily functions.


Thyroid hormones are needed for bone and brain development during pregnancy and infancy too. T4 and T3 also support neurotransmitter production and function and moods but more on that in a bit.


Thyroid function is mainly regulated by thyroid-stimulating hormone or TSH. Its job is to control thyroid hormone secretion and keep it in the Goldie Locks zone; not too little, not too much.

Iodine deficiency

Severe iodine deficiency is still a major nutritional deficiency concern in some parts of the world. Because the iodine content of soil varies geographically, the iodine content of food is inconsistent & unreliable for the most part. In fact, iodine deficiency is the most common cause of preventable neuro-developmental delay in the world (Ref).


Goiter used to be a real concern in Canada too before iodine was added to table salt which virtually eliminated goiter, the most extreme form of iodine deficiency. Iodine deficiency disorders and poor iodine intake-related problems result from inadequate thyroid hormone levels in the body. Not enough iodine, not enough thyroid hormone.


FUN FACT: TSH secretion increases when iodine intake is below about 100 mcg/day. TSH continues to rise as iodine intake decreases/remains poor (Ref)


TSH increases thyroidal iodine uptake from the blood and increases the production of thyroid hormone. However, very low iodine intakes can reduce thyroid hormone production even in the presence of elevated TSH levels. Elevated TSH suggests the thyroid is being told to STEP UP production of its hormones. Unfortunately thyroid hormone production might be lagging if iodine ain’t around to help.

Iodine deficiency test

There isn’t a blood test to assess iodine status. A review of your usual diet, supplement use, and use of iodized table can help health professionals get a ballpark sense of your intake. This kind of assessment is qualitative and it can help you understand if you’re a risk of inadequate iodine intake.


Urinary iodine test

More than 90% of ingested iodine is excreted in your urine within 24-48 hours. Therefore your daily iodine intakes can be measured based on how much you’re peeing out. This is more accurate than a diet recall but it can support a diet recall which is used to screen those at risk.

WHO iodine deficiency is defined as:

  • < 150 mcg/day for pregnant women
  • < 100 mcg/day for everyone else including children, adolescents, adults and breast-feeding women


Iodine patch test

In the natural health world, the iodine skin patch test is promoted as a way to assess an iodine deficiency. It goes like this. Buy an iodine tincture (2% iodine), rub some on your skin (which will turn brown). The iodine patch will fade. It always does.


The thinking is that if it fades quickly, your body has absorbed it quickly (within 4 to 12 hours) because you’re deficient. Your body sucked it up like a dry sponge does water. If it fades slowly (still medium brown 24 hrs later), you’re not deficient because your body isn’t as ‘thirsty’ for iodine.


Problem is, this has never been validated and there aren’t any clinical trials to support this. As a compound, iodine is very volatile and evaporates easily. Not just from the skin, but from iodized salt which is why iodized table salt can be unreliable.


Grilled cod fish steak - by Doug Cook RD

Iodine health benefits

Iodine is crucial for healthy thyroid function. In the thyroid gland, iodine combines with the amino acid tyrosine to form the thyroid hormones T4 (thyroxine) and T3 (triiodothyronine); a mouthful for sure. T3 is the active form and basically does it all.


T3 is the one that regulates physical growth and development in both fetuses and infants, promotes intellectual/brain development. T3 regulates metabolic rate, body temperature, protein metabolism, heart rate, and lung function. It’s also responsible for testosterone & estrogen production, immune function, neurotransmitter production and more (1).


Almost all of your body’s functions, in nearly every tissue rely on thyroid hormones. Their actions and influence are so wide ranging that you cannot live without them.


Healthy Comfort – 9 Foods That Help Your Mood


Iodine is a nutrient of concern during pregnancy & beyond because of its role in infant and child  growth and brain development. Even a modest deficiency, long before goiter shows up, can result in a loss of 10-15 IQ points (2). This is why prenatal supplements have extra iodine and should not be overlooked.

Iodine and the brain

Because iodine is crucial for a healthy and happy thyroid, and therefore T4 & T3 production & function, this precious mineral has a big role in good mental health. Iodine helps ensure that there’s enough T4 and T3 in the brain to help it activate key neurotransmitters such as dopamine, norepinepherine, serotonin, GABA, and acetylcholine.


Without out enough T4 & T3, people may experience insomnia, fatigue, depression, and difficulty concentrating and focusing.


DID YOU KNOW? A healthy thyroid gland will use about 80 mcg of iodine daily to make thyroid hormones


Iodine’s role in mood regulation

As hormones, T4 & T3 regulate gene expression. Think of genes as a light switch and hormones as your hand; you use you hand to turn on, or turn off the switch. Similarly, hormones turn on, or turn off genes.


Not consuming enough iodine can result in not having enough T4 & T3 to turn on the genes that regulate the very neurotransmitters that regulate your mood.


Thyroid hormones and neurotransmitters

Serotonin: studies have shown that low levels of T3 results in low levels of serotonin which can lead to decreased mood/happiness, depression, changes in social behaviour, and increased anxiety (3)


Dopamine: T3 also regulates the action of dopamine (which is converted into norepinepherine/epinepherine) which affects memory, feelings of pleasure & reward, focus & attention, and improved behaviour and cognition (4)


Mental Health. The Neurotransmitter Edition, Part 1


GABA: GABA is the ‘zen’ neurotransmitter. Think of it as your brain’s natural benzo. T3 is needed for optimal GABA production and therefore helps you respond to stress better. Low T3 via low iodine intake can result in impaired GABA production and increased anxiety (5).


Acetylcholine: not as well known as other neurotransmitters, acetylcholine is need for learning and forming new memories. Low iodine intake and low T4 & T3 can result in low acetylcholine levels in the brain affecting cognition, memory, recall and mood.


Norepinepherine: not as well known as other neurotransmitters, acetylcholine is need for learning and forming new memories. Low iodine intake and low T4 & T3 can result in low acetylcholine levels in the brain affecting cognition, memory, recall and mood.


A bowl of seaweed in a dish on a table with chopsticks


Foods that contain iodine?

There are several natural sources of iodine. There are also foods that contain iodine as does iodized salt. Get the recommended amounts of iodine by eating a variety of iodine rich foods, including:

  • Fish (such as cod and tuna), shrimp, and other seafood, which are generally rich in iodine.
  • Seaweeds (nori, wakame, kombu kelp)
  • Lima beans
  • Dairy products (such as milk, yogurt, and cheese) are important sources of iodine in North American diets.
  • Fruits and vegetables. The amount depends on the iodine in the soil where they grew and in any fertilizer that was used.
  • Iodized salt, which is readily available in North America. Processed foods, however, such as canned soups, almost never contain iodized salt

Who’s at risk for iodine deficiency?

  • People living in regions with iodine-deficient soils
  • People with marginal iodine status who eat foods with goitrogens (6)
  • Those who don’t use iodized salt (this includes sea salt, Himalayan salt)
  • Pregnant women
  • Breast-fed and weaning infants
  • Breast-feeding women
  • People on special diets
  • Those with poor quality diets

Are you getting enough iodine?

Studies of North Americans suggest that the vast majority of people are technically consuming enough iodine to prevent a clinical deficiency (using urinary iodine excretion).


The results below are from the ongoing Canadian Community Health Survey which suggests that most Canadians meet the World Health Organization’s goal of 0.79 to 1.57 micromolar/L (of urine). US studies have similar findings.


Urinary iodine concentration in different age groups


But not everyone is hitting the mark. About 22% of Canadians have a mild iodine deficiency and another 7% have a moderate deficiency.


In other words,  almost 1/3 of the population may be at risk of not gettiing the full brain &  mental health benefits of iodine and that’s a concern.


In medicine, when it comes to matters of nutrition, it’s assumed that if a person doesn’t have a classic nutrient deficiency, in this case goiter, then there’s nothing to worry about. This is a very old school approach to nutritional biochemistry rooted in the concept of preventing deficiency-related diseases.


The problem with this approach, is that it doesn’t take into consideration that people have different absolute requirements for any given nutrient. People don’t absorb nutrients to the same degree, and the field of nutrigenomics has shown us that a person’s unique genes affect their ability to use nutrients to their fullest extent and more.


Simply striving to prevent a deficiency may not be the best goal when it comes to your health, you may want to go beyond just crossing the finish line and go for gold.


This is no less true when it comes to a nutrient like iodine, one which we assume everyone is getting/utilizing enough of especially when it comes to something a precious as your mental health.


Food sources of iodine - by Doug Cook RD

Are iodine supplements safe?

Supplements may be needed if you don’t get enough iodine in your diet. There are different types of iodine supplements; some are very high in iodine and potentially problemtaic. Iodine is found in many multivitamins with minerals and multi-mineral formulas and as stand alone iodine supplements.


Adults should avoid prolonged use of doses higher than 1100 mcg per day (the upper tolerable intake level, UL) without proper medical supervision. In children, doses should not exceed 200 mcg per day for children 1 to 3 years old, 300 mcg per day for children 4 to 8 years old. As well, 600 mcg per day for children 9 to 13 years old, and 900 mcg per day for adolescents. These are the upper tolerable intake levels (UL).


Some in the natural medicine world promote the use of very high doses of iodine which really should be avoided. The RDA is 150 mcg or 0.15 mg per day and proponents like Dr David Brownstein and Dr Mark Sircus to name a couple are suggesting 25 to 50 mg, or 25,000 – 50,000 mcg per day. This can increase the risk for hyperthyroidism. (7).


There are little to no meaningful well-designed, placebo-controlled studies showing that these kinds of doses are either safe or effective.


Lugol’s iodine

A popular supplement in the natural health world. It is a solution of elemental iodine (5%) and potassium iodide (KI, 10%) together with distilled water. Each drop has 6.25 mg of iodine (6250 mcg) – 2.5 mg iodine and 3.75 potassium iodide. Patients are often prescribed take 2 drops per dose providing about 12.50 mg or 12, 500 mcg of iodine.


Nascent iodine

“Nascent iodine” was once used as simply another name for sodium iodide (an iodide atom bound to sodium). The term was then used by the American mysticist, Edgar Cayce, to describe a free form of iodine (i.e., a single atom of iodide unbound to any other atom) – apparently created by adding electromagnetic or another form of energy.


However, when this free form of iodide is exposed to a positively charged ion, such as sodium or potassium, as it would be in a liquid supplement, it will bind with these to form sodium iodide or potassium iodide. Therefore, if you are buying a supplement promoted as “nascent iodine”, it is most likely sodium iodide or potassium iodine


Potassium iodine

Common salt of iodine found in many supplements, either in a multivitamin and minerals or as a stand alone iodine supplement. Doses typically range from 200 to 800 mcg per dose.


Multivitamins with minerals and multi-minerals

Typically contain different forms of iodine. Common salts include as sodium or potassium iodine, potassium iodate, potassium iodide, or sodium iodide. Doses in most multis range from 50 to 220 mcg for prenatal formulas


Doug Cook RDN is a Toronto based integrative and functional nutritionist and dietitian with a focus on digestive, gut, and mental health.  Follow me on Facebook, Instagram and Twitter.


Comments 5

  1. Thompson
    July 5, 2018

    By: Doug Cook, thank you for your blog post.Really thank you! Awesome.

  2. Alice Archambault
    October 31, 2018


    I chose this article to read because I am very interested in Iodine and how it affects mental health
    Recently, I was having problems with ulcers in my mouth. A friend kept suggesting I use iodine drops on them. Eventually I listened. I ordered some from a company on line. I Googled this nutrient thoroughly before I chose one. I bought Lugols 2% Iodine.
    I started putting drops on the mouth ulcers, inside of, with a Q-tip. ! need to say first that I take Lexapro, Lamictal, and Abilify every day. I didn’t know that I was missing something in my mentality until I noticed a delightful difference. I assumed the iodine was making this difference.
    I felt more chipper mentally. I felt so so much better. Amazing.. I walk with a cane and my feet still drag a bit, I have some balance issue that I’ve had to deal with for a few years now.
    Listen to this! I began to notice I was walking better too. I still need to use a cart while shopping, and my three wheeled walker. I believe that the iodine has made a huge difference here. I haven’t used an electric cart while shopping. I am a bit more stable with my legs.
    Finally, I believe the 150 mcg. or ten drops of iodine has worked a miracle in and with me!! It has been two months now, and mentally I feel so much better inside my body.
    I am grateful with this consistent change. My attitude in general is strong and I feel so stable.
    I have babbled here, Thanks for listening and reading, And especially, thank you for this article. Interesting and on target!
    Thank you

    Alice L Archambault

  3. viacutan olie
    June 26, 2019

    Looking forward to reading more. Great blog post.Thanks Again.

  4. Ronnie C
    August 4, 2019

    As a single parent exhausted from way too much to do I had been in search of much needed energy. I read somewhere that Iodine,Selenium,and Zinc are the three important thyroid minerals.I tried sea kelp powder and lugol’s iodine, neither helped. Potassium Iodine is the winner, I take 225 mcg iodine,100 mcg selenium yeast and 25 mg zinc gluconate and my metabolism soars. also sleeping better and in better mood.Sometimes I take this combo up to three times a day. The only other supplements I take occasionally are natural vitamin E, Vitamin C, and N-Acetyl-Cysteine.

    1. Doug Cook
      August 5, 2019

      That’s interesting…did you ever have your thyroid functions and blood indices tested?

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