Creatine powder on a wooden table top

Creatine for Gut Health and Mental Health?

Creatine 2 1 - Creatine for Gut Health and Mental Health?

[Last updated March 2019]

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Creatine monohydrate is probably best known for it’s use as an ergogenic aid, something that enhances physical performance.


Creatine exploded onto the fitness & sport nutrition scene in the 90s; almost everyone I knew at the gym was using it and why not?


There’s good science to support its use for exercise and fitness-related activities (1, 2, 3, 4). Creatine is stored as ‘creatine-phosphate’ (CrP), sometimes called ‘phosphocreatine’, which helps to regenerate ATP. ATP is a molecule that provides energy including energy needed for muscle contractions.


Having more creatine on board ensures your working muscles recover quicker and fully. This allows more reps to be squeezed out during exercise.

Phosphocreatine - Creatine for Gut Health and Mental Health?

Turns out that muscles are not the only organ or body system that benefits from the extra energy that CrP offers. Creatine benefits the gut, the brain and by extension mental health and even the skin.


This makes complete sense since every cell in your body makes and needs creatine for energy. Who knew?


So? Would you benefit from extra creatine in your diet?

Creatine and its many health benefits

Gut health

As a supplement for gut health, how does creatine benefit?


Creatine, a commonly used dietary supplement, plays an important role in maintaining gut barrier function, i.e. preventing leaky gut.


Given that dysregulation of the gut barrier (the defense between the intestinal contents and the blood stream) is a hallmark of inflammatory bowel disease, it is plausible that creatine supplementation may reduce intestinal disease severity.


A case study in the American College of Gastroenterology Case Reports Journal found just that (5). A 33-year-old male was seen for evaluation of a 2-year history of hematochezia and anal pain thought secondary to non-healing anal fissures.


In addition to rectal bleeding, the patient reported a long history of cramping, abdominal pain and loose stools.


Given the patient’s long-standing GI symptoms, anal tag, and hemorrhoids, a colonoscopy was performed to evaluate for IBD. The patient was taking just over 1 g of creatine daily which was stopped and he was then started on mesalamine (an anti-inflammatory).


Over the following 4 months, the patient reported progressively more frequent and severe abdominal pain. A repeat colonoscopy at that time revealed worsening ileitis with more extensive ulceration.


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Given this progressive ileitis, more intensive therapy was planned. Prior to initiating new agents, however, the patient requested a trial of his previous creatine supplement, as he felt his symptoms were better when taking creatine and worsened once he stopped.


Upon stopping mesalamine and reinitiating creatine at 1,034 g/day, the patient reported a significant improvement in his symptoms.


A repeat colonoscopy was performed 6 months later to assess endoscopic Crohn’s activity on “creatine monotherapy.” The prior extensive ulceration and inflammation appeared significantly improved, and only one, small ulcer was seen.


FUN FACT: creatine benefits gut health


Clinical trials are now underway to study the effects of dietary creatine on mucosal inflammation in IBD; this was the first reported case of a patient with IBD who experienced significant clinical improvement with creatine supplementation


Turns out creatine plays an important role in the energy metabolism of intestinal epithelial cells and therefore tissues of the digestive tract.


It is needed to maintain gut barrier function (when the digestive tract keeps the ‘bad’ stuff out and lets the good stuff in), support normal digestion and enzyme secretions and gut homeostasis or the ability to self-regulate/balance itself (6, 7, 8)


Lamb braised shank - Creatine for Gut Health and Mental Health?


At the end of the day, finding an effective gut health supplement is a great consideration for improving digestive well-being.

Gut health diet

As part of your gut health diet strategy, getting more creatine would be helpful. Foods rich in creatine are animal-based. Some of the top sources include:

  • Fish
    • Fatty fish like herring, salmon, trout, sardines, and mackerel also provide omega 3 (including DPA) which lower gut inflammation
  • Beef
  • Pork
  • Lamb
  • Chicken

Brain health

Like with the digestive tract, finding solid brain health supplements with evidence to back them up is another good strategy.


And, what’s good for the gut is good for the brain; a function of the gut-brain axis . So gut-loving creatine stands to benefit your noggin as well.


You’ll probably be surprised to hear then that it’s actually been over a decade now since scientists demonstrated that supplementing creatine can significantly enhance cognition and delay mental fatigue.


Vegetarians will especially benefit from extra creatine since creatine is normally found in animal proteins such as meats, fish and poultry. It’s true that the the body can produce some creatine but we normally rely on dietary sources to provide most of what we need.


If we’re not getting enough from our diets, vegetarian or not, supplemental creatine will top up the tank and help us meet and exceed our minimum daily requirements.


Steak - Creatine for Gut Health and Mental Health?


The effects of creatine on the brain are so potent that when vegetarians were given 5 g of creatine/day for 6 weeks, a double-blind, placebo-controlled study found that working memory and intelligence (as measured by Raven’s Progressive Matrices) were significantly improved compared to the placebo subjects (9).


FUN FACT: Creatine benefits brain health


But creatine supplementation can benefit non-vegetarians too. A 2009 study showed that creatine is capable of increasing I.Q, attention span and working memory in non-vegetarians also (10).


Research is also underway to see how creatine supplementation may work as possible therapy for various neurological degenerative diseases like Huntington’s, ALS and Alzheimer’s diseases (11, 12, 13, 14).


Creatine supplements help to increase CrP levels in the brain cells, or neurons, like it does muscle tissue and the cells of the digestive tract. Cells with more CrP are able to boost energy levels; more energy may lead to better cognitive performance.

Mental health

Creatine for mental health? It’s not as far fetched as it sounds.


Creatine metabolism is altered in those with psychiatric and mood disorders including anxiety (15). Whether the neuron’s own creatine synthesis impairment leads to mental health issues or vice versa is not completely understood.


Finding support for depression and anxiety is really important, so-called antidepressants,  now referred to as mood stabilizers, are a magic bullet. A large 2010 meta-analysis concluded that mood stabilizers work no better than placebo in mild to moderate depression (16).


As with other nutrient studies that found benefit from targeted nutrient supplementation, creatine can help with mood disorders. This makes sense as the neurons need to have proper and optimal structure to function well.


The human body is made up of elements that are derived from the foods we eat. Solid nutrition is needed for the repair and maintenance of all cells and tissues, including brain cells.


When it comes to function, a working brain cell needs optimal energy metabolism and this is where creatine can help with mood disorders like depression and anxiety (17, 18).


One such example was with a small group of women receiving Lexapro (escitalopram) and half of the subjects received 5 g of creatine. By the second week, the women taking the creatine had much better effect, and their scores showed they were not clinically depressed. Those in the placebo group had some improvement, but still scored in the depressed zone (19).


This is important since mood stabilizers need at least 6 weeks to see if there’s any benefit and up to 12 weeks to reach optimal effect.


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Getting enough creatine

If you’re an omnivore and include animal foods in your diet, look at the list of foods above and see if there’s room to include more of them. Like it or not, these are the best sources and the best way to ensure you’re getting enough creatine.


Whether you eat meat, fish and chicken, if you’re not eating them regularly you might not be getting enough creatine.


Getting the amount of creatine needed for optimal benefits can be challenging even for omnivores making supplementation key to getting the most that creatine has to offer. It’s virtually impossible for vegetarians and vegans to get enough.


A few of my favourite brands are Allmax Creatine Monohydrate*, OPTIMUM NUTRITION*, Kaizen Naturals* and Genuine Health Fermented BCAA + Creatine*


Most of the discussion around plant-based nutrition focuses on the usual suspects of protein, zinc, iron, calcium, vitamin B12.


To a lesser extend other nutrients of concern are vitamin D, long-chain fatty acids EPA, DPA and DHA but it’s more nuanced than that. Creatine is never talked about but it’s something that’s touched on in my post Vegan? It’s more than B12 and zinc that’s at risk.


Doug Cook RDN is a Toronto based integrative and functional nutritionist and dietitian with a focus on digestive, gut, mental health.  Follow me on FacebookInstagram and Twitter.